Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 12/20 | 0.46 |
| ▸ | CNR2 | P34972 | 8/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363935 | 0.93 | CNR1 (0.51) | CNR1CNR2MCL1GCGRMAPK14 | |
| SCHEMBL1404496 | 0.90 | CNR1 (0.49) | CNR1CNR2MCL1KDM4EHPGD | |
| SCHEMBL3401285 | 0.85 | MCL1 (0.45) | CNR1CNR2MCL1GCGRMAPK14 | |
| SCHEMBL1404528 | 0.85 | KDM4E (0.51) | CNR1CNR2MCL1KDM4EHPGD | |
| SCHEMBL5363205 | 0.83 | KDM4E (0.49) | CNR1CNR2MCL1KDM4EHPGD | |
| SCHEMBL19835567 | 0.83 | MCL1 (0.55) | CNR1MCL1GCGRMAPK14KDM4E | |
| SCHEMBL3100284 | 0.80 | KDM4E (0.50) | CNR1CNR2MCL1KDM4EHPGD | |
| SCHEMBL5363847 | 0.78 | KDM4E (0.59) | CNR1MCL1GCGRMAPK14KDM4E | |
| SCHEMBL19835568 | 0.77 | KDM4E (0.51) | CNR1MCL1GCGRMAPK14KDM4E | |
| SCHEMBL9587750 | 0.73 | KDM4E (0.73) | CNR1MCL1KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728141-B2 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-06-01 | — | — | US | disclosed |
| EP-1682550-B1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2009-12-23 | — | — | EP | disclosed |
| US-20070032517-A1 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. | 2007-02-08 | — | — | US | disclosed |
| EP-1682550-A4 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2007-01-03 | — | — | EP | disclosed |
| CN-1875021-A | Substituted naphthyridinone derivatives | MERCK & CO INC (US) | 2006-12-06 | — | — | CN | disclosed |
| EP-1682550-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | Merck & Co., Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047285-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032517-A1 | Substituted naphthyridinone derivatives | CNR1, CNR2, MAG | CNR1 1/4885CNR2 2/4885MCL1 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.