Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 13/20 | 0.46 |
| ▸ | CNR2 | P34972 | 12/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404496 | 0.89 | CNR1 (0.49) | KDM4EMCL1CNR1CNR2ALDH1A1 | |
| SCHEMBL19835567 | 0.87 | MCL1 (0.55) | KDM4EMCL1CNR1MEN1KMT2A | |
| SCHEMBL5363847 | 0.82 | KDM4E (0.59) | KDM4EMCL1CNR1METKDR | |
| SCHEMBL5363935 | 0.82 | CNR1 (0.51) | KDM4EMCL1CNR1CNR2ALDH1A1 | |
| SCHEMBL5363205 | 0.82 | KDM4E (0.49) | KDM4EMCL1CNR1CNR2MEN1 | |
| SCHEMBL19835568 | 0.81 | KDM4E (0.51) | KDM4EMCL1CNR1MEN1KMT2A | |
| SCHEMBL3621034 | 0.80 | CNR1 (0.46) | KDM4EMCL1CNR1CNR2MEN1 | |
| SCHEMBL3401285 | 0.80 | MCL1 (0.45) | KDM4EMCL1CNR1CNR2MEN1 | |
| SCHEMBL1404528 | 0.78 | KDM4E (0.51) | KDM4EMCL1CNR1CNR2ALDH1A1 | |
| SCHEMBL9587750 | 0.74 | KDM4E (0.73) | KDM4EMCL1CNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362045-B2 | 5,6-diaryl pyridines substituted in the 2- and 3-position, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-01-29 | — | — | US | disclosed |
| US-20100256202-A1 | 5,6-DIARYL PYRIDINES SUBSTITUTED IN THE 2- AND 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256202-A1 | 5,6-DIARYL PYRIDINES SUBSTITUTED IN THE 2- AND 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | ALK, ROS1, CYP11B2 | KDM4E 736/4885MCL1 1351/4885CNR1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.