Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31108808 | 1.00 | PDGFRB (0.48) | PDGFRBKDRMAPK1ATMKDM4E | |
| SCHEMBL31705858 | 0.82 | KDM4E (0.51) | PDGFRBKDRMAPK1ATMKDM4E | |
| SCHEMBL29726958 | 0.82 | ALDH1A1 (0.51) | MAPK1ATMKDM4EL3MBTL1P2RY12 | |
| SCHEMBL473919 | 0.82 | ALDH1A1 (0.51) | MAPK1ATMKDM4EL3MBTL1P2RY12 | |
| SCHEMBL41129 | 0.82 | KDM4E (0.51) | PDGFRBKDRMAPK1ATMKDM4E | |
| SCHEMBL5320922 | 0.82 | CYP2C9 (0.50) | MAPK1L3MBTL1P2RY12ALDH1A1 | |
| SCHEMBL23774958 | 0.82 | PSMD14 (0.43) | PDGFRBKDRMAPK1ATMKDM4E | |
| SCHEMBL16421752 | 0.81 | ATM (0.51) | PDGFRBKDRMAPK1ATMKDM4E | |
| SCHEMBL3655489 | 0.81 | MAPK1 (0.47) | MAPK1ATMKDM4EL3MBTL1P2RY12 | |
| SCHEMBL198706 | 0.81 | MAPK1 (0.47) | MAPK1ATMKDM4EL3MBTL1P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230087118-A1 | IMIDAZO[1,2-a]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | BIOGEN MA INC. | 2023-03-23 | — | — | US | disclosed |
| EP-2593451-B1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AND -PYRIDINES | BAYER IP GMBH (DE) | 2015-08-19 | — | — | EP | disclosed |
| US-8975265-B2 | Substituted imidazo[1,2-a]pyrimidines and —pyridines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-10 | — | — | US | disclosed |
| US-20130190332-A1 | Substituted Imidazo[1,2-a]pyrimidines and -pyridines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-25 | — | — | US | disclosed |
| EP-2593451-A2 | SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AND -PYRIDINES | Bayer Intellectual Property GmbH (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007345-A2 | SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AND -PYRIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230087118-A1 | IMIDAZO[1,2-a]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | IRAK4, IRAK2, IRAK1 | PDGFRB 490/4885KDR 188/4885MAPK1 308/4885 |
| US-20130190332-A1 | Substituted Imidazo[1,2-a]pyrimidines and -pyridines | PIK3CA, PIK3CD, PIK3CB | PDGFRB 113/4885KDR 223/4885MAPK1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.