Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.40 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618925 | 0.92 | GUCY1B2 (0.44) | KDM4EGUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3620263 | 0.88 | GUCY1B2 (0.41) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3233794 | 0.87 | GUCY1B2 (0.43) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3628181 | 0.86 | GUCY1B2 (0.46) | KDM4EALDH1A1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3626707 | 0.84 | MEN1 (0.48) | KDM4EALDH1A1MEN1KMT2AGUCY1B2 | |
| SCHEMBL3624462 | 0.83 | EPHX2 (0.40) | KDM4EALDH1A1MEN1KMT2AGUCY1B2 | |
| SCHEMBL4005292 | 0.81 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3230062 | 0.81 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1SMN1; SMN2 | |
| SCHEMBL3629056 | 0.80 | GUCY1B2 (0.45) | KDM4EMEN1KMT2ALMNAGUCY1B2 | |
| SCHEMBL7937211 | 0.80 | GUCY1B2 (0.43) | KDM4EALDH1A1MEN1KMT2AGUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |