Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 11/20 | 0.43 |
| ▸ | GUCY1A2 | P33402 | 11/20 | 0.43 |
| ▸ | GUCY1A1 | Q02108 | 11/20 | 0.43 |
| ▸ | GUCY1B1 | Q02153 | 11/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000642 | 0.89 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3234865 | 0.86 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3626707 | 0.86 | MEN1 (0.48) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NPC1 | |
| SCHEMBL3998970 | 0.80 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3620263 | 0.80 | GUCY1B2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NPC1 | |
| SCHEMBL4000871 | 0.80 | L3MBTL1 (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1ALDH1A1 | |
| SCHEMBL3622541 | 0.80 | KDM4E (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NPC1 | |
| SCHEMBL7934714 | 0.79 | MAPT (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3229753 | 0.78 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3624462 | 0.78 | EPHX2 (0.40) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |