Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628788 | 0.90 | KMT2A (0.45) | MEN1KMT2AMAPK1CCR5GUCY1B2 | |
| SCHEMBL7937211 | 0.86 | GUCY1B2 (0.43) | MEN1KMT2AMAPK1GUCY1B2GUCY1A2 | |
| SCHEMBL3233357 | 0.85 | MEN1 (0.47) | MEN1KMT2AMAPK1CCR5GUCY1B2 | |
| SCHEMBL3620263 | 0.85 | GUCY1B2 (0.41) | MEN1KMT2AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3622541 | 0.84 | KDM4E (0.41) | MEN1KMT2AMAPK1GUCY1B2GUCY1A2 | |
| SCHEMBL15153415 | 0.82 | GUCY1B2 (0.49) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3624462 | 0.82 | EPHX2 (0.40) | MEN1KMT2AMAPK1GUCY1B2GUCY1A2 | |
| SCHEMBL3624510 | 0.82 | CCR5 (0.42) | MEN1KMT2AMAPK1CCR5GUCY1B2 | |
| SCHEMBL3622280 | 0.81 | LMNA (0.41) | MEN1KMT2ACCR5GUCY1B2GUCY1A2 | |
| SCHEMBL3627423 | 0.80 | PTPN11 (0.46) | MEN1KMT2AMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |