Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 6/20 | 0.39 |
| ▸ | GLA | P06280 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 5/20 | 0.38 |
| ▸ | CASP7 | P55210 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | IGLV6-57 | P01721 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5590828 | 0.73 | ALDH1A1 (0.78) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL13869309 | 0.73 | ALDH1A1 (0.86) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL8132354 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL28721602 | 0.68 | ALDH1A1 (0.77) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL29569907 | 0.68 | ALDH1A1 (0.77) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL5705313 | 0.68 | EP300 (0.89) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL13869289 | 0.68 | ALDH1A1 (0.72) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL13869376 | 0.68 | ALDH1A1 (0.68) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL29249851 | 0.68 | ALDH1A1 (0.75) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL28720726 | 0.68 | ALDH1A1 (0.75) | ALDH1A1KDM4EL3MBTL1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240103013-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2024-03-28 | — | — | US | disclosed |
| EP-4273549-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3557254-B1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2021-12-15 | — | — | EP | disclosed |
| EP-3557255-B1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2021-11-17 | — | — | EP | disclosed |
| US-11162953-B2 | Protein binding domains stabilizing functional conformational states of GPCRS and uses thereof | VIB VZW (BE) | 2021-11-02 | — | — | US | disclosed |
| US-11162954-B2 | Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof | VIB VZW (BE) | 2021-11-02 | — | — | US | disclosed |
| EP-2593792-B1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2019-11-13 | — | — | EP | disclosed |
| US-10458993-B2 | Assay for assessing conformational stability of membrane protein | HEPTARES THERAPEUTICS LIMITED (GB) | 2019-10-29 | — | — | US | disclosed |
| EP-3557255-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB vzw (BE) | 2019-10-23 | — | — | EP | disclosed |
| EP-3557257-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB vzw (BE) | 2019-10-23 | — | — | EP | disclosed |
| WO-2013179062-A2 | ASSAYS | HEPTARES THERAPEUTICS LIMITED (GB) | 2013-12-05 | — | — | WO | disclosed |
| US-20130183287-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2013-07-18 | — | — | US | disclosed |
| US-20130137856-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-30 | — | — | US | disclosed |
| EP-2593792-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB vzw (BE) | 2013-05-22 | — | — | EP | disclosed |
| EP-2593791-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB vzw (BE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012120315-A2 | MUTANT PROTEINS AND METHODS FOR PRODUCING THEM | HEPTARES THERAPEUTICS LIMITED (GB) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012098413-A1 | MUTANT G-PROTEIN COUPLED RECEPTOR PROTEINS AND METHODS FOR PRODUCING THEM | HEPTARES THERAPEUTICS LIMITED (GB) | 2012-07-26 | — | — | WO | disclosed |
| US-20120165507-A1 | MUTANT PROTEINS AND METHODS FOR PRODUCING THEM | HEPTARES THERAPEUTICS LIMITED (GB) | 2012-06-28 | — | — | US | disclosed |
| WO-2012007594-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007593-A1 | PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF | VIB VZW (BE) | 2012-01-19 | — | — | WO | disclosed |