Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623064 | 1.00 | SYK (0.41) | SYKHCAR3IRAK4CHEK1MAPKAPK2 | |
| SCHEMBL2177577 | 0.86 | MAPKAPK2 (0.50) | IRAK4CHEK1MAPKAPK2SMYD3JAK2 | |
| SCHEMBL2177570 | 0.86 | MAPKAPK2 (0.50) | IRAK4CHEK1MAPKAPK2SMYD3JAK2 | |
| SCHEMBL13463627 | 0.85 | KIT (0.41) | SYKHCAR3IRAK4CHEK1MAPKAPK2 | |
| SCHEMBL3631179 | 0.80 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL3631182 | 0.80 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL1937018 | 0.79 | IRAK4 (0.40) | SYKHCAR3IRAK4CHEK1MAPKAPK2 | |
| SCHEMBL1937016 | 0.79 | IRAK4 (0.40) | SYKHCAR3IRAK4CHEK1MAPKAPK2 | |
| SCHEMBL26676727 | 0.77 | MCHR1 (0.43) | HCAR3IRAK4CHEK1MAPKAPK2SMYD3 | |
| SCHEMBL3630689 | 0.73 | ROCK2 (0.59) | SYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |