Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177577 | 1.00 | MAPKAPK2 (0.50) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13463627 | 0.88 | KIT (0.41) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL3623068 | 0.86 | SYK (0.41) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL3623064 | 0.86 | SYK (0.41) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL1937018 | 0.79 | IRAK4 (0.40) | MAPKAPK2CHEK1JAK2IRAK4KIT | |
| SCHEMBL1937016 | 0.79 | IRAK4 (0.40) | MAPKAPK2CHEK1JAK2IRAK4KIT | |
| SCHEMBL1938044 | 0.77 | ROCK2 (0.52) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL1938046 | 0.77 | ROCK2 (0.52) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL6154502 | 0.76 | ROCK2 (0.51) | MAPKAPK2CHEK1KITFLT3SMYD3 | |
| SCHEMBL6154499 | 0.76 | ROCK2 (0.51) | MAPKAPK2CHEK1KITFLT3SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166161-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166161-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166161-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166161-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ROCK1, ROCK2, RHOT2 | MAPKAPK2 415/4885CHEK1 1873/4885JAK2 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.