Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | FPR3 | P25089 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | GPR183 | P32249 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | APLNR | P35414 | 1/20 | 0.53 |
| ▸ | GLP1R | P43220 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623245 | 0.93 | HTR6 (0.58) | HTR6HTR2CHTR7ADRB2CHRM2 | |
| SCHEMBL3623910 | 0.80 | HTR6 (0.47) | HTR6HTR2CHTR7ADRB2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL3625913 | 0.80 | HTR6 (0.52) | HTR6HTR7CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL3617270 | 0.78 | HTR6 (0.68) | HTR6HTR7HTR1DHTR1BCYP3A4 | |
| Trifluoroacetic Acid SCHEMBL3623393 | 0.78 | HTR6 (0.48) | HTR6CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL3624424 | 0.78 | HTR6 (0.53) | HTR6CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL3622318 | 0.78 | HTR6 (0.52) | HTR6HTR7CYP3A4CYP2D6 | |
| SCHEMBL1537789 | 0.77 | HTR6 (0.63) | HTR6HTR2CHTR7ADRB2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL3616450 | 0.77 | HTR6 (0.53) | HTR6HTR7HTR1DHTR1BCYP3A4 | |
| Trifluoroacetic Acid SCHEMBL3622703 | 0.77 | HTR6 (0.68) | HTR6HTR7HTR1DHTR1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-B1 | INDOLES AS 5-HT6 MODULATORS | PROXIMAGEN LTD (GB) | 2012-10-31 | — | — | EP | disclosed |
| US-7812017-B2 | 4-substituted indole and indoline compounds | BIOVITRUM AB (PUBL.) (SE) | 2010-10-12 | — | — | US | disclosed |
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| US-20080032968-A1 | New compounds | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2008-02-07 | — | — | US | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032968-A1 | New compounds | HTR6, HTR1B, HTR1A | HTR6 1/4885HTR2C 15/4885HTR7 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.