Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.36 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3625631 | 1.00 | ADRB2 (0.36) | ADRB2CASRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5580686 | 0.89 | ADRB2 (0.38) | ADRB2CASRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5580683 | 0.89 | ADRB2 (0.38) | ADRB2CASRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13807616 | 0.87 | ADRB2 (0.37) | ADRB2CASRADRB1ADRB3ALDH1A1 | |
| SCHEMBL3627413 | 0.87 | RAB9A (0.36) | ADRB2SLC6A2SLC6A3ADRB1ADRB3 | |
| SCHEMBL3627411 | 0.87 | RAB9A (0.36) | ADRB2SLC6A2SLC6A3ADRB1ADRB3 | |
| SCHEMBL3626476 | 0.81 | ADRB2 (0.44) | ADRB2ELANE | |
| SCHEMBL3626479 | 0.81 | ADRB2 (0.44) | ADRB2ELANE | |
| SCHEMBL4273560 | 0.81 | ADRB2 (0.51) | ADRB2 | |
| SCHEMBL4273553 | 0.81 | ADRB2 (0.51) | ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730103-B1 | FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR | PFIZER LTD (GB) | 2010-05-26 | — | — | EP | disclosed |
| EP-1730103-A1 | FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR | Pfizer Limited (GB) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092840-A1 | FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR | PFIZER LIMITED (GB) | 2005-10-06 | — | — | WO | disclosed |