Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | JUN | P05412 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627132 | 0.81 | KDM1A (0.48) | TOP2AKMOMEN1KMT2ACDK1 | |
| SCHEMBL319801 | 0.80 | CYP19A1 (0.51) | KMOMEN1KMT2ACDK1CDK2 | |
| SCHEMBL3625411 | 0.79 | IDO1 (0.45) | GSK3BDYRK1AKDM4ECDK2 | |
| SCHEMBL31011728 | 0.77 | CYP19A1 (0.49) | JAK2KDM4EMEN1KMT2ACDK1 | |
| SCHEMBL3622296 | 0.77 | CYP19A1 (0.49) | JAK2KDM4EMEN1KMT2ACDK1 | |
| SCHEMBL443863 | 0.74 | KIF11 (0.47) | GABRA1GABRG2GABRB3GABRA3KMO | |
| SCHEMBL5990281 | 0.74 | KDM1A (0.50) | TOP2AKDM4ETRPV1L3MBTL1MEN1 | |
| SCHEMBL15674606 | 0.73 | TOP2A (0.44) | TOP2ANOS3NOS2MEN1KMT2A | |
| SCHEMBL21508484 | 0.73 | KMO (0.50) | GABRA1GABRG2GABRB3GABRA3KMO | |
| SCHEMBL4455134 | 0.73 | KMO (0.44) | GABRA1GABRG2GABRB3GABRA3KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |