SCHEMBL3626533 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	HTR5A	P47898	9/20	0.39

▸	NOS2	P35228	1/20	0.37

▸	CREBBP	Q92793	2/20	0.35

▸	BRPF1	P55201	1/20	0.35

▸	IDO1	P14902	1/20	0.34

▸	PBRM1	Q86U86	1/20	0.33

▸	TNKS2	Q9H2K2	1/20	0.33

▸	AADAT	Q8N5Z0	1/20	0.33

▸	ABCB1	P08183	1/20	0.33

▸	SMN1; SMN2	Q16637	1/20	0.33

▸	BRD4	O60885	2/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7571631	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL172934	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL18324162	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL18269674	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL18271939	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL29501187	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL19308765	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL7571638	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL18324164	0.77	HTR5A (0.41)	HTR5ANOS2CREBBPBRPF1IDO1
SCHEMBL30570964	0.73	CREBBP (0.50)	HTR5ANOS2CREBBPBRPF1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2142516-A1	PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS	Sanofi-Aventis (FR)	2010-01-13	—	—	EP	disclosed
WO-2008121670-A1	PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS	SANOFI-AVENTIS (FR)	2008-10-09	—	—	WO	disclosed