Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.30 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377401 | 0.82 | — | — | |
| Alcohol SCHEMBL3498911 | 0.80 | TSHR (0.35) | CTSKTSHR | |
| 2,2,3-Trimethylbutane SCHEMBL11333900 | 0.73 | TSHR (0.53) | TSHRTHRBOPRM1LMNATRPM8 | |
| Hexane SCHEMBL27875071 | 0.70 | SMN1; SMN2 (0.41) | CTSKTSHRTHRBOPRM1LMNA | |
| Hexane SCHEMBL7875362 | 0.69 | TSHR (0.47) | TSHRTHRBLMNADNM1SLC22A1 | |
| Hexane SCHEMBL28065491 | 0.69 | OPRM1 (0.43) | TSHRTHRBOPRM1DNM1 | |
| Hexane SCHEMBL28709670 | 0.67 | TSHR (0.64) | TSHRTHRBLMNADNM1SLC22A1 | |
| Hexane SCHEMBL27748725 | 0.67 | TSHR (0.64) | TSHRTHRBOPRM1LMNATRPM8 | |
| Hexane SCHEMBL1048428 | 0.67 | TSHR (0.64) | TSHRTHRBOPRM1LMNATRPM8 | |
| Hexane SCHEMBL1554946 | 0.67 | TSHR (0.44) | TSHRTHRBLMNADNM1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20060084665-A1 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084665-A1 | Quinolizinone compound and use thereof as HIV integrase inhibitor | NQO2, ACE, CDK20 | CTSK 1066/4885TSHR 4846/4885THRB 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.