Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 10/20 | 0.43 |
| ▸ | GUCY1A2 | P33402 | 10/20 | 0.43 |
| ▸ | GUCY1A1 | Q02108 | 10/20 | 0.43 |
| ▸ | GUCY1B1 | Q02153 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628181 | 0.87 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3618925 | 0.86 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3628846 | 0.82 | GUCY1B2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3628719 | 0.81 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3624888 | 0.81 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3626258 | 0.80 | GUCY1B2 (0.39) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3627404 | 0.80 | GUCY1B2 (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3622541 | 0.79 | KDM4E (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3624884 | 0.79 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3616728 | 0.78 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |