Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.38 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.38 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.38 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005456 | 0.88 | SCN9A (0.47) | F10SCN9AS1PR5KDM4EGUCY1B2 | |
| SCHEMBL3626258 | 0.84 | GUCY1B2 (0.39) | SCN9AKDM4EPOLBGUCY1B2GUCY1A2 | |
| SCHEMBL3627318 | 0.83 | LIPE (0.46) | F10SCN9ASMN1; SMN2NPSR1FFAR4 | |
| SCHEMBL3995969 | 0.80 | SCN9A (0.54) | F10SCN9AS1PR5GUCY1B2GUCY1A2 | |
| SCHEMBL3227166 | 0.79 | SMN1; SMN2 (0.48) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTGER1 | |
| SCHEMBL3998983 | 0.79 | SCN9A (0.45) | SCN9AS1PR5KDM4EGUCY1B2GUCY1A2 | |
| SCHEMBL4001140 | 0.77 | SCN9A (0.49) | F10SCN9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3994172 | 0.76 | SCN9A (0.44) | F10SCN9AS1PR5KDM4EGUCY1B2 | |
| SCHEMBL4001501 | 0.76 | SCN9A (0.47) | F10SCN9AS1PR5GUCY1B2GUCY1A2 | |
| SCHEMBL3624902 | 0.76 | KDM4E (0.42) | SCN9AKDM4EPOLBGUCY1B2GUCY1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |