Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.73 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.35 |
| ▸ | WDR5 | P61964 | 3/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362745 | 0.95 | CENPE (0.81) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3462519 | 0.87 | CENPE (0.85) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL13161478 | 0.87 | CENPE (0.85) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL360386 | 0.86 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL360380 | 0.86 | CENPE (0.85) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2106962 | 0.86 | CENPE (0.85) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| Gsk-923295A SCHEMBL368558 | 0.84 | CENPE (1.00) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| Gsk-923295A SCHEMBL2101077 | 0.84 | CENPE (1.00) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| Gsk-923295A SCHEMBL1492164 | 0.84 | CENPE (1.00) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| Gsk-923295A SCHEMBL29379288 | 0.84 | CENPE (1.00) | CENPEKIFC1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582682-A1 | METHODS OF TREATING LUNG DISEASE | Cytokinetics, Inc. (US) | 2013-04-24 | — | — | EP | claimed |
| WO-2012009097-A1 | METHODS OF TREATING LUNG DISEASE | CYTOKINETICS, INC. (US) | 2012-01-19 | — | — | WO | claimed |
| EP-2582682-A1 | METHODS OF TREATING LUNG DISEASE | Cytokinetics, Inc. (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2012009097-A1 | METHODS OF TREATING LUNG DISEASE | CYTOKINETICS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |