Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627139 | 0.93 | SYK (0.38) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3628794 | 0.91 | MEN1 (0.45) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3628869 | 0.90 | KDM4C (0.39) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3620278 | 0.90 | RAB9A (0.50) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3996759 | 0.89 | KEAP1 (0.51) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL4000225 | 0.83 | KEAP1 (0.52) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3626353 | 0.83 | MAPT (0.44) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3626358 | 0.83 | MAPT (0.44) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL4003529 | 0.83 | KEAP1 (0.49) | RAB9AMEN1KMT2ANPC1ATM | |
| SCHEMBL3996644 | 0.83 | KEAP1 (0.49) | RAB9AMEN1KMT2ANPC1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |