Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.53 |
| ▸ | ANO1 | Q5XXA6 | 10/20 | 0.53 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27815387 | 0.89 | MEN1 (0.54) | MEN1KMT2ARAB9ANPC1NLRP3 | |
| SCHEMBL27815448 | 0.84 | MEN1 (0.48) | MEN1KMT2ARAB9ANPC1NLRP3 | |
| SCHEMBL3627300 | 0.81 | MAPT (0.72) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL3629109 | 0.81 | MAPT (0.72) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL3628382 | 0.81 | MEN1 (0.80) | MEN1KMT2ARAB9ANPC1NLRP3 | |
| SCHEMBL3629623 | 0.81 | MEN1 (0.80) | MEN1KMT2ARAB9ANPC1NLRP3 | |
| SCHEMBL3631128 | 0.81 | MAPT (0.66) | MEN1KMT2ARAB9ANPC1NLRP3 | |
| SCHEMBL27815385 | 0.78 | MEN1 (0.54) | MEN1KMT2ARAB9ANPC1NLRP3 | |
| SCHEMBL12337660 | 0.76 | ALDH1A1 (0.53) | MEN1KMT2ARAB9ANPC1ANO1 | |
| SCHEMBL3629605 | 0.76 | ANO1 (0.70) | MEN1KMT2ARAB9ANPC1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200607-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035818-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-03-19 | — | — | WO | claimed |