Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PTPRC | P08575 | 2/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.59 |
| ▸ | PTPA | Q15257 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629109 | 1.00 | MAPT (0.72) | MAPTTP53THRBPTPN1MEN1 | |
| SCHEMBL3620747 | 0.90 | THRB (0.80) | MAPTTP53THRBPTPN1MEN1 | |
| SCHEMBL21247385 | 0.89 | TP53 (0.72) | MAPTTP53THRBPTPN1MEN1 | |
| SCHEMBL3631128 | 0.89 | MAPT (0.66) | MAPTTP53THRBMEN1KMT2A | |
| SCHEMBL3629358 | 0.88 | THRB (0.63) | MAPTTP53THRBPTPN1MEN1 | |
| SCHEMBL13837701 | 0.86 | ANO1 (0.73) | MAPTTP53PTPN1PTPRCPTPN2 | |
| SCHEMBL3629702 | 0.84 | TP53 (0.82) | MAPTTP53PTPN1MEN1KMT2A | |
| SCHEMBL8289507 | 0.83 | PTPN1 (0.69) | MAPTTP53THRBPTPN1MEN1 | |
| SCHEMBL3629623 | 0.83 | MEN1 (0.80) | TP53MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3628382 | 0.83 | MEN1 (0.80) | TP53MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524765-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120289587-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8263641-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| EP-2200607-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| WO-2009035818-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289587-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | MAPT 1478/4885TP53 2681/4885THRB 1606/4885 |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | MAPT 1478/4885TP53 2681/4885THRB 1606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.