Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 3/20 | 0.54 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345130 | 1.00 | CXCL8 (0.54) | CXCL8FABP4FABP5HDAC1HDAC8 | |
| SCHEMBL3630480 | 1.00 | CXCL8 (0.54) | CXCL8FABP4FABP5HDAC1HDAC8 | |
| SCHEMBL1346100 | 0.88 | CXCL8 (0.52) | CXCL8FABP4FABP5AKR1C3AKR1C2 | |
| SCHEMBL11833301 | 0.88 | CXCL8 (0.52) | CXCL8FABP4FABP5AKR1C3AKR1C2 | |
| SCHEMBL11124056 | 0.80 | CXCL8 (0.49) | CXCL8FABP4FABP5AKR1C3AKR1C2 | |
| SCHEMBL1345669 | 0.79 | PTGS1 (0.54) | CXCL8PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL3817959 | 0.79 | PTGS1 (0.54) | CXCL8PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL8875079 | 0.79 | PTGS1 (0.54) | CXCL8PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL11826285 | 0.79 | HTR2A (0.60) | CXCL8PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL11094201 | 0.78 | CXCL8 (0.50) | CXCL8FABP4FABP5AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229942-B1 | 2-Aryl-propionic acids and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2012-08-29 | — | — | EP | claimed |
| EP-2229942-A1 | 2-Aryl-propionic acids and pharmaceutical compositions containing them | Dompe S.p.A. (IT) | 2010-09-22 | — | — | EP | claimed |
| US-8063242-B2 | for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion | DOMPE PHA.R.MA S.P.A. (IT) | 2011-11-22 | — | — | US | disclosed |
| US-8063242-B2 | for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion | DOMPE PHA.R.MA S.P.A. (IT) | 2011-11-22 | — | — | US | disclosed |