Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 3/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11833301 | 0.87 | CXCL8 (0.52) | CXCL8XIAPAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1346100 | 0.87 | CXCL8 (0.52) | CXCL8XIAPAKR1C3AKR1C2PTGS1 | |
| SCHEMBL11093240 | 0.86 | XIAP (0.41) | CXCL8XIAPFABP4FABP5CAMK2A | |
| SCHEMBL11191908 | 0.84 | PTGS1 (0.51) | CXCL8PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL11124056 | 0.82 | CXCL8 (0.49) | CXCL8XIAPAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1345130 | 0.78 | CXCL8 (0.54) | CXCL8AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL3630480 | 0.78 | CXCL8 (0.54) | CXCL8AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL3628494 | 0.78 | CXCL8 (0.54) | CXCL8AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL5672222 | 0.75 | CXCL8 (0.63) | CXCL8AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL663906 | 0.75 | CXCL8 (0.63) | CXCL8AKR1C3AKR1C2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472433-A | Phenoxyphenyl acetic acids and their medicinal use | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0008226-B1 | PHENYL-ALKANOIC ACID DERIVATIVES, THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-02 | — | — | EP | disclosed |
| EP-0008226-A2 | Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-02-20 | — | — | EP | disclosed |