SCHEMBL3628531

SCHEMBL3628531

O=C1Oc2ccccc2CN1N1CCCCC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
KMT2A Q03164 2/20 0.37
HPGD P15428 3/20 0.36
TSHR P16473 3/20 0.36
GAA P10253 4/20 0.36
MAPT P10636 3/20 0.36
ALOX15 P16050 1/20 0.36
P2RX4 Q99571 1/20 0.36
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HTT P42858 2/20 0.35
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 2/20 0.32
KDM4E B2RXH2 1/20 0.32
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11355286 0.71 KMT2A (0.69) MAOAMAOBKMT2ATSHRGAA
SCHEMBL10075481 0.70 BRD4 (0.46) MAOAMAOBKMT2ATSHRGAA
SCHEMBL2784144 0.70 POLB (0.44) MAOAMAOBKMT2ATSHRMAPT
SCHEMBL2784147 0.68 NPC1 (0.51) MAOAMAOBKMT2AHPGDTSHR
SCHEMBL3626605 0.68 MGLL (0.41) MAOAMAOBKMT2ATSHRNPC1
Hydrochloric Acid SCHEMBL11261560 0.68 BRD4 (0.51) KMT2AHPGDTSHRGAAMAPT
SCHEMBL25650200 0.67 MAOA (0.39) MAOAMAOBKMT2ATSHRGAA
SCHEMBL22401867 0.67 MAOA (0.39) MAOAMAOBKMT2ATSHRGAA
SCHEMBL2767899 0.67 TSHR (0.45) MAOAMAOBKMT2ATSHRGAA
SCHEMBL2783566 0.65 DRD3 (0.46) KMT2AHPGDTSHRMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7795251-B2 3,4-dihydro-benzo[e][1,3]oxazin-2-ones NOVARTIS AG (CH) 2010-09-14 US disclosed
EP-1874742-A1 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES Novartis AG (CH) 2008-01-09 EP disclosed
WO-2006108671-A1 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES NOVARTIS AG (CH) 2006-10-19 WO disclosed
US-6090805-A Tocolytic oxytocin receptor antagonists MERCK & CO., INC. (US) 2000-07-18 US disclosed