Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357627 | 0.82 | PHGDH (0.40) | PHGDHCA2CA12CA1CA9 | |
| SCHEMBL17963023 | 0.79 | — | — | |
| SCHEMBL18536860 | 0.76 | MGLL (0.46) | PHGDHCA2CA12CA1CA9 | |
| SCHEMBL15833455 | 0.74 | MGLL (0.48) | PHGDHCA2CA12CA1CA9 | |
| SCHEMBL25703358 | 0.74 | CA2 (0.45) | CA2CA12CA1CA9CHKA | |
| SCHEMBL5995283 | 0.74 | CA2 (0.35) | PHGDHCA2CA12CA1CA9 | |
| SCHEMBL17289446 | 0.72 | — | — | |
| SCHEMBL5995932 | 0.71 | CA2 (0.33) | CA2CA12CA1CA9CHKA | |
| SCHEMBL5995930 | 0.71 | CA2 (0.33) | CA2CA12CA1CA9CHKA | |
| SCHEMBL3431670 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935272-A1 | PYRAZOLE SUBSTITUTED IMIDAZOPYRAZINES AS CASEIN KINASE 1 D/E INHIBITORS | Bristol-Myers Squibb Company (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100540-A1 | PYRAZOLE SUBSTITUTED IMIDAZOPYRAZINES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-06-26 | — | — | WO | disclosed |
| EP-2225226-A1 | COMPOUNDS AND METHOD FOR TREATMENT OF CANCER | Critical Outcome Technologies, Inc. (CA) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009079797-A9 | COMPOUNDS AND METHOD FOR TREATMENT OF CANCER | CRITICAL OUTCOME TECHNOLOGIES, INC. (CA) | 2009-10-01 | — | — | WO | disclosed |
| WO-2009079797-A1 | COMPOUNDS AND METHOD FOR TREATMENT OF CANCER | CRITICAL OUTCOME TECHNOLOGIES, INC. (CA) | 2009-07-02 | — | — | WO | disclosed |