Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628618 | 1.00 | ROCK2 (0.57) | ROCK2ROCK1MAPK8ALDH1A1POLB | |
| SCHEMBL12408599 | 0.90 | ROCK2 (0.71) | ROCK2ROCK1MAPK8ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL1937888 | 0.89 | ROCK2 (0.70) | ROCK2ROCK1MAPK8ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL1937886 | 0.89 | ROCK2 (0.70) | ROCK2ROCK1MAPK8ALDH1A1POLB | |
| SCHEMBL3622961 | 0.88 | ROCK2 (0.62) | ROCK2ROCK1MAPK8ALDH1A1SYK | |
| SCHEMBL3622963 | 0.88 | ROCK2 (0.62) | ROCK2ROCK1MAPK8ALDH1A1SYK | |
| SCHEMBL1937142 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1MAPK8KITFLT3 | |
| SCHEMBL1937146 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1MAPK8KITFLT3 | |
| SCHEMBL3627381 | 0.84 | ROCK2 (0.79) | ROCK2ROCK1MAPK8KITFLT3 | |
| SCHEMBL3627383 | 0.84 | ROCK2 (0.79) | ROCK2ROCK1MAPK8KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |