Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.50 |
| ▸ | CCR6 | P51684 | 3/20 | 0.40 |
| ▸ | CCR7 | P32248 | 2/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628624 | 1.00 | HCAR3 (0.50) | HCAR3CCR6CCR7SIRT6GSK3B | |
| SCHEMBL1936258 | 0.85 | HCAR3 (0.49) | HCAR3CCR6CCR7SIRT6GSK3B | |
| SCHEMBL1936260 | 0.85 | HCAR3 (0.49) | HCAR3CCR6CCR7SIRT6GSK3B | |
| SCHEMBL2817349 | 0.81 | HDAC3 (0.46) | HCAR3CCR6CCR7SIRT6MAPK1 | |
| SCHEMBL29944834 | 0.81 | HDAC3 (0.46) | HCAR3CCR6CCR7SIRT6MAPK1 | |
| SCHEMBL22998284 | 0.79 | HCAR3 (0.49) | HCAR3PDGFRBPDGFRASMYD3 | |
| Fumaric Acid SCHEMBL30856933 | 0.78 | HCAR3 (0.42) | HCAR3CCR6CCR7MAPK1 | |
| SCHEMBL1937510 | 0.77 | HCAR3 (0.42) | HCAR3CCR6CCR7SIRT6GSK3B | |
| SCHEMBL1937508 | 0.77 | HCAR3 (0.42) | HCAR3CCR6CCR7SIRT6GSK3B | |
| SCHEMBL15228235 | 0.75 | HCAR3 (0.58) | HCAR3CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |