Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | CCR7 | P32248 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944834 | 0.92 | HDAC3 (0.46) | HCAR3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2817349 | 0.92 | HDAC3 (0.46) | HCAR3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29582918 | 0.85 | HCAR3 (0.49) | HCAR3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL16048397 | 0.85 | HCAR3 (0.49) | HCAR3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17075516 | 0.84 | HCAR3 (0.48) | HCAR3HDAC3HDAC1HDAC2HDAC6 | |
| Lithium Ion SCHEMBL17075514 | 0.78 | HDAC3 (0.45) | HCAR3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3628624 | 0.78 | HCAR3 (0.50) | HCAR3MAPK1CCR7CCR6 | |
| SCHEMBL3628627 | 0.78 | HCAR3 (0.50) | HCAR3MAPK1CCR7CCR6 | |
| SCHEMBL1936258 | 0.77 | HCAR3 (0.49) | HCAR3FLT3CCR7CCR6 | |
| SCHEMBL1936260 | 0.77 | HCAR3 (0.49) | HCAR3FLT3CCR7CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11938132-B2 | Stable pharmaceutical composition for oral administration | ASTELLAS PHARMA INC. (JP) | 2024-03-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11938132-B2 | Stable pharmaceutical composition for oral administration | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SLC20A1, RCC1 | FLT3 2633/4885HCAR3 2625/4885HDAC3 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.