SCHEMBL3628702

SCHEMBL3628702

COC(=O)N1C=Cc2ccccc2C1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 3/20 0.46
HDAC3 O15379 1/20 0.43
HSD17B3 P37058 1/20 0.40
NOTUM Q6P988 1/20 0.37
TAS1R3 Q7RTX0 3/20 0.36
TAS1R1 Q7RTX1 3/20 0.36
TAS1R2 Q8TE23 3/20 0.36
NAMPT P43490 2/20 0.36
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
PRMT5 O14744 1/20 0.35
WDR77 Q9BQA1 1/20 0.35
BCHE P06276 1/20 0.35
ALOX15 P16050 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
TRPA1 O75762 1/20 0.34
RYR2 Q92736 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
LMNA P02545 1/20 0.34
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29493251 0.84 HDAC3 (0.41) HDAC3HSD17B3NAMPTMEN1KMT2A
SCHEMBL15056964 0.84 HDAC3 (0.41) HDAC3HSD17B3NAMPTMEN1KMT2A
SCHEMBL15056226 0.83 P2RX4 (0.39) P2RX4HDAC3HSD17B3NOTUMBCHE
SCHEMBL323681 0.83 MAPK1 (0.45) HDAC3HSD17B3NAMPTMEN1KMT2A
SCHEMBL324810 0.83 LIPE (0.44) HDAC3HSD17B3KMT2ABCHESMN1; SMN2
SCHEMBL324830 0.83 LIPE (0.44) TAS1R3TAS1R1TAS1R2BCHESMN1; SMN2
SCHEMBL323769 0.83 TSHR (0.42) P2RX4HDAC3HSD17B3NAMPT
SCHEMBL324125 0.83 P2RX4 (0.53) P2RX4HDAC3HSD17B3NAMPTMEN1
SCHEMBL6168375 0.81 HSD17B3 (0.49) P2RX4HDAC3HSD17B3NOTUMTAS1R3
SCHEMBL324821 0.81 SMN1; SMN2 (0.55) HDAC3HSD17B3MEN1KMT2ABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105884771-B Trifluoromethyl pyrpole and isoquinilone derivatives and its synthetic method 上海大学 2017-11-10 CN disclosed
EP-3004082-A1 CXCR7 RECEPTOR MODULATORS Actelion Pharmaceuticals Ltd. (CH) 2016-04-13 EP disclosed
WO-2014191929-A1 CXCR7 RECEPTOR MODULATORS ACTELION PHARMACEUTICALS LTD (CH) 2014-12-04 WO disclosed
EP-2150534-A1 ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS H. Lundbeck A/S (DK) 2010-02-10 EP disclosed
CN-100564358-C The method of a kind of preparation 4-(3, the 4-dichlorophenoxy) piperidines ASTRAZENECA AB (SE) 2009-12-02 CN disclosed
WO-2008131779-A1 ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS H. LUNDBECK A/S (DK) 2008-11-06 WO disclosed
CN-100352807-C substituted piperidine compounds ASTRAZENECA AB (SE) 2007-12-05 CN disclosed
CN-1907968-A Method for making 4-(3,4-dichlorophenoxy)piperidine ASTRAZENECA AB (SE) 2007-02-07 CN disclosed
CN-1633414-A Compound (I) ASTRAZENECA AB (SE) 2005-06-29 CN disclosed
EP-1530472-A1 ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
CN-1500080-A Fused heterocyclic compounds ����ҩƷ��ҵ��ʽ���� 2004-05-26 CN disclosed
WO-2004014379-A1 ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 WO disclosed