⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336086 | 0.97 | CES2 (0.52) | — | |
| Water SCHEMBL11679288 | 0.95 | CES2 (0.50) | — | |
| Water SCHEMBL11679290 | 0.95 | CES2 (0.50) | — | |
| SCHEMBL14905737 | 0.94 | — | — | |
| SCHEMBL1370935 | 0.88 | — | — | |
| SCHEMBL27622993 | 0.85 | — | — | |
| SCHEMBL27496040 | 0.84 | CES2 (0.41) | — | |
| SCHEMBL14206645 | 0.79 | TSHR (0.46) | — | |
| SCHEMBL28822104 | 0.79 | MAPT (0.31) | — | |
| SCHEMBL28099042 | 0.79 | TSHR (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250092042-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2025-03-20 | — | — | US | disclosed |
| US-12157737-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2024-12-03 | — | — | US | disclosed |
| US-20240043425-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2024-02-08 | — | — | US | disclosed |
| US-11708366-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2023-07-25 | — | — | US | disclosed |
| US-11708366-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2023-07-25 | — | — | US | disclosed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-20220048909-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-02-17 | — | — | US | disclosed |
| US-20220048909-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-02-17 | — | — | US | disclosed |
| WO-2022034529-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2022-02-17 | — | — | WO | disclosed |
| CN-102471205-A | Herbicidally active 2- (substituted-phenyl) -cyclopentane-1, 3-dione derivatives | SYNGENTA LTD | 2012-05-23 | — | — | CN | disclosed |
| CN-101735294-A | Prodrug of L-nucleoside | BRIGHTGENE BIO MEDICAL TECHNOL | 2010-06-16 | — | — | CN | disclosed |
| US-7695863-B2 | rechargeable batteries having excellent battery cycle properties, electrical capacity and storage characteristic during charging, comprising electrodes and a nonaqueous electrolytic solution containing a dicarbonyl compound as an additive | UBE INDUSTRIES, LTD. (JP) | 2010-04-13 | — | — | US | disclosed |
| CN-100577679-C | Prodrugs of L-nucleosides | BORUI BIOPHARMACEUTICAL TECHNOLOGY SUZHOU CO LTD | 2010-01-06 | — | — | CN | disclosed |
| EP-2133342-A1 | PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR, PREPARATION METHODS AND USES THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2009-12-16 | — | — | EP | disclosed |
| US-20080102377-A1 | rechargeable batteries having excellent battery cycle properties, electrical capacity and storage characteristic during charging, comprising electrodes and a nonaqueous electrolytic solution containing a dicarbonyl compound as an additive | UBE INDUSTRIES, LTD (JP) | 2008-05-01 | — | — | US | disclosed |
| CN-1891710-A | Prodrugs of L-nucleosides | BORUI BIOPHARMACEUTICAL TECHNO (CN) | 2007-01-10 | — | — | CN | disclosed |
| US-6300306-B1 | TREATING HARD SURFACES, POLYOXYALKYLENE UNITS AND SULFONATEDPOLYAMIDES AND SULFONATED POLYFUNCTIONAL UNITS AND BINDING GROUPS WITH ESTER | RHODIA CHIMIE (FR) | 2001-10-09 | — | — | US | disclosed |
| US-4046763-A | INTERMEDIATE FOR ULTRAVIOLET LIGHT ABSORBERS | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-06 | — | — | US | disclosed |