Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | SOD1 | P00441 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631375 | 0.98 | CTSK (0.48) | CTSKKCNH2NAMPTMAPK1ITGB2 | |
| SCHEMBL3633387 | 0.91 | GSK3A (0.53) | CTSKKCNH2MAPK1ITGB2ICAM1 | |
| SCHEMBL3633096 | 0.90 | NAMPT (0.53) | NAMPTGSK3AGSK3BQPCTKDM4E | |
| SCHEMBL3632700 | 0.87 | GSK3A (0.48) | CTSKKCNH2NAMPTMAPK1ITGB2 | |
| SCHEMBL3630804 | 0.85 | KDM4E (0.50) | NAMPTITGB2ICAM1ITGALGSK3A | |
| SCHEMBL3632000 | 0.85 | SMN1; SMN2 (0.54) | CTSKKCNH2NAMPTMAPK1ITGB2 | |
| SCHEMBL3630627 | 0.85 | QPCT (0.56) | NAMPTGSK3AGSK3BQPCTKDM4E | |
| SCHEMBL3633391 | 0.85 | GSK3A (0.54) | NAMPTMAPK1ITGB2ICAM1ITGAL | |
| SCHEMBL3631542 | 0.84 | KDM4E (0.49) | CTSKKCNH2MAPK1ITGB2ICAM1 | |
| SCHEMBL3627894 | 0.83 | SOD1 (0.52) | NAMPTGSK3AGSK3BQPCTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142536-A1 | AMINOPYRIMIDINE DERIVATIVES AS GLUTAMINYL CYCLASE INHIBITORS | Probiodrug AG (DE) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008128984-A1 | AMINOPYRIMIDINE DERIVATIVES AS GLUTAMINYL CYCLASE INHIBITORS | PROBIODRUG AG (DE) | 2008-10-30 | — | — | WO | disclosed |