Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.37 |
| ▸ | TYK2 | P29597 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 5/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629566 | 1.00 | ROCK2 (0.62) | ROCK2ROCK1GSK3BMAPK8MAPK9 | |
| SCHEMBL12408597 | 0.89 | ROCK2 (0.78) | ROCK2ROCK1GSK3BMAPK8MAPK9 | |
| Hydrochloric Acid SCHEMBL1937109 | 0.88 | ROCK2 (0.76) | ROCK2ROCK1GSK3BMAPK8MAPK9 | |
| Hydrochloric Acid SCHEMBL1937110 | 0.88 | ROCK2 (0.76) | ROCK2ROCK1GSK3BMAPK8MAPK9 | |
| SCHEMBL3627381 | 0.88 | ROCK2 (0.79) | ROCK2ROCK1MAPK8MAPK9SYK | |
| SCHEMBL3627383 | 0.88 | ROCK2 (0.79) | ROCK2ROCK1MAPK8MAPK9SYK | |
| SCHEMBL3622963 | 0.85 | ROCK2 (0.62) | ROCK2ROCK1MAPK8MAPK9SYK | |
| SCHEMBL3622961 | 0.85 | ROCK2 (0.62) | ROCK2ROCK1MAPK8MAPK9SYK | |
| SCHEMBL1936225 | 0.83 | ROCK2 (0.55) | ROCK2ROCK1GSK3BMAPK8MAPK9 | |
| SCHEMBL1936224 | 0.83 | ROCK2 (0.55) | ROCK2ROCK1GSK3BMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |