Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 5/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362683 | 0.89 | ERN1 (0.38) | ERN1GPR183THRB | |
| SCHEMBL371298 | 0.86 | ERN1 (0.35) | ERN1GPR183KCNH2THRB | |
| SCHEMBL365266 | 0.83 | ERN1 (0.35) | ERN1LMNA | |
| SCHEMBL364766 | 0.75 | GPR183 (0.33) | GPR183KCNH2 | |
| SCHEMBL363777 | 0.72 | KMT2A (0.39) | KCNH2ALDH1A1LMNAKIF11 | |
| SCHEMBL362479 | 0.72 | HDAC3 (0.30) | — | |
| SCHEMBL364445 | 0.70 | CYP3A4 (0.35) | — | |
| SCHEMBL363931 | 0.65 | TSHR (0.39) | KCNH2ALDH1A1LMNA | |
| SCHEMBL363954 | 0.65 | HDAC6 (0.32) | — | |
| SCHEMBL362959 | 0.62 | GPR183 (0.39) | GPR183KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |