Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371298 | 0.80 | ERN1 (0.35) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL363931 | 0.77 | TSHR (0.39) | KMT2AMEN1RAB9ALMNAPABPC1 | |
| SCHEMBL440368 | 0.76 | KIF11 (0.41) | KMT2AMEN1LMNAALDH1A1TSHR | |
| SCHEMBL364766 | 0.74 | GPR183 (0.33) | KCNH2 | |
| SCHEMBL362960 | 0.72 | ERN1 (0.36) | LMNAALDH1A1KIF11KCNH2 | |
| SCHEMBL12187544 | 0.71 | NPC1 (0.41) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL363152 | 0.71 | KCNN4 (0.45) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL364699 | 0.68 | GAA (0.36) | KMT2ANPC1RAB9AALDH1A1POLB | |
| SCHEMBL22079377 | 0.67 | NNMT (0.48) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL77481 | 0.67 | KDM4E (0.47) | KMT2AMEN1RAB9APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |