Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803172 | 0.81 | MAPT (0.38) | MEN1KMT2ALMNACYP3A4PMP22 | |
| SCHEMBL4321314 | 0.78 | MEN1 (0.33) | MEN1KMT2ALMNACYP3A4CYP2C9 | |
| SCHEMBL2804738 | 0.75 | KCNQ2 (0.34) | KCNQ2 | |
| SCHEMBL1721447 | 0.75 | KIT (0.43) | MEN1KMT2ALMNACYP3A4CYP2C9 | |
| SCHEMBL1973881 | 0.74 | DGAT1 (0.36) | NFKB1MAPK1SMN1; SMN2KCNQ2 | |
| SCHEMBL4077922 | 0.70 | MEN1 (0.44) | MEN1KMT2ALMNACYP3A4CYP2C9 | |
| SCHEMBL1969124 | 0.69 | KCNQ2 (0.33) | TSHRALDH1A1KCNQ2LIPE | |
| SCHEMBL15025980 | 0.69 | KCNQ2 (0.33) | KCNQ2LIPE | |
| SCHEMBL28486528 | 0.69 | RAB9A (0.44) | MEN1KMT2ALMNACYP3A4CYP2C9 | |
| SCHEMBL1785988 | 0.68 | TSHR (0.46) | MEN1KMT2ALMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152865-A1 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS | THOMAS JEFFERSON UNIVERSITY (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-2081915-A2 | BICYCLIC HETEROAROMATIC COMPOUNDS | Glaxo Group Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008140449-A1 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS | THOMAS JEFFERSON UNIVERSITY (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008140450-A1 | METHODS OF TREATMENT AND PREVENTION OF METABOLIC BONE DISEASES AND DISORDERS | THOMAS JEFFERSON UNIVERSITY (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008048866-A2 | BICYCLIC HETEROAROMATIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | WO | disclosed |