Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.73 |
| ▸ | PTPRC | P08575 | 2/20 | 0.73 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.73 |
| ▸ | PTPA | Q15257 | 2/20 | 0.73 |
| ▸ | PTPRF | P10586 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.60 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622362 | 0.90 | TP53 (1.00) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL21247385 | 0.85 | TP53 (0.72) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL13837701 | 0.84 | ANO1 (0.73) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL12314194 | 0.84 | MEN1 (0.84) | MEN1KMT2ANPC1ANO1ANO2 | |
| SCHEMBL3627300 | 0.84 | MAPT (0.72) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL3629109 | 0.84 | MAPT (0.72) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL13837658 | 0.82 | PRKCZ (0.66) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL13901723 | 0.81 | PTPN1 (0.80) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL14123489 | 0.80 | PRKCZ (0.63) | TP53MAPTPTPN1PTPRCPTPN2 | |
| SCHEMBL5919026 | 0.79 | PRKCZ (0.62) | TP53MAPTPTPN1PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524765-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120289587-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8263641-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| EP-2200607-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| WO-2009035818-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289587-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | TP53 2681/4885MAPT 1478/4885PTPN1 3156/4885 |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | TP53 2681/4885MAPT 1478/4885PTPN1 3156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.