Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | F13A1 | P00488 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 2/20 | 0.38 |
| ▸ | TGM1 | P22735 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627322 | 0.87 | F10 (0.39) | PIK3CBMTORPIK3CGF10MEN1 | |
| SCHEMBL3629011 | 0.85 | GBA1 (0.44) | PIK3CBPIK3CGF10MEN1KMT2A | |
| SCHEMBL3091559 | 0.85 | PIK3CG (0.46) | PIK3CBMTORPIK3CGMEN1KMT2A | |
| SCHEMBL3629695 | 0.81 | MAPT (0.44) | PIK3CBPIK3CGF10MEN1KMT2A | |
| SCHEMBL3635713 | 0.81 | HCRTR1 (0.51) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL3084310 | 0.76 | PIK3CA (0.41) | PIK3CBMTORPIK3CGMAPTPIK3CA | |
| SCHEMBL3633555 | 0.75 | SLC6A7 (0.44) | F10MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3095681 | 0.75 | PIK3CG (0.47) | PIK3CBMTORPIK3CGMEN1KMT2A | |
| SCHEMBL3630265 | 0.75 | F10 (0.37) | PIK3CBPIK3CGF10MAPTKDM4E | |
| SCHEMBL14021969 | 0.74 | GBA1 (0.43) | PIK3CBMTORPIK3CGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |