Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | GBA1 | P04062 | 3/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629011 | 0.91 | GBA1 (0.44) | F10PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL3630355 | 0.87 | PIK3CB (0.39) | F10PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3629695 | 0.87 | MAPT (0.44) | F10PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL3635713 | 0.86 | HCRTR1 (0.51) | PIK3CAGBA1MEN1KMT2A | |
| SCHEMBL3079976 | 0.80 | PIK3CA (0.47) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL3630265 | 0.80 | F10 (0.37) | F10PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL14021851 | 0.79 | PIK3CA (0.39) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL3627366 | 0.78 | SMO (0.43) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL3633555 | 0.77 | SLC6A7 (0.44) | F10MEN1KMT2A | |
| SCHEMBL3628462 | 0.77 | GBA1 (0.41) | PIK3CAPIK3CBPIK3CGPIK3CDGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |