Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 6/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630676 | 1.00 | ROCK2 (0.46) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL13463828 | 0.89 | ROCK2 (0.47) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL1937738 | 0.89 | ROCK2 (0.58) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL1937740 | 0.89 | ROCK2 (0.58) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL3622961 | 0.87 | ROCK2 (0.62) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL3623059 | 0.87 | ROCK2 (0.46) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL3629563 | 0.87 | ROCK2 (0.46) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL3622963 | 0.87 | ROCK2 (0.62) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL3629561 | 0.87 | ROCK2 (0.46) | ROCK2ROCK1SYKMAPK8MAPK9 | |
| SCHEMBL3623057 | 0.87 | ROCK2 (0.46) | ROCK2ROCK1SYKMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |