Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686827 | 0.86 | TP53 (0.44) | CNR1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL6167915 | 0.77 | TP53 (0.40) | FLT1FLT4KDRCNR1LMNA | |
| SCHEMBL11458875 | 0.77 | IDO1 (0.51) | CNR1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL3663698 | 0.76 | CNR1 (0.53) | CNR1KMT2ALMNAATMBRD4 | |
| SCHEMBL480139 | 0.76 | MEN1 (0.37) | KMT2ASMN1; SMN2 | |
| SCHEMBL3658338 | 0.74 | MEN1 (0.46) | KMT2ALMNATP53SMN1; SMN2HTT | |
| SCHEMBL1978297 | 0.74 | HSD17B10 (0.46) | LMNATP53BRD4HDAC4HDAC7 | |
| SCHEMBL5188701 | 0.74 | MAPT (0.44) | FLT1FLT4KDRCNR1KMT2A | |
| SCHEMBL473977 | 0.73 | MAPK1 (0.41) | KMT2ALMNATP53NPSR1HTT | |
| SCHEMBL2010819 | 0.72 | S1PR1 (0.38) | KMT2ALMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146997-A1 | SUBSTITUTED FURO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008127585-A1 | SUBSTITUTED FURO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-10-23 | — | — | WO | disclosed |