Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686827 | 0.90 | TP53 (0.44) | TP53LMNAHTTCNR1CNR2 | |
| SCHEMBL11458875 | 0.83 | IDO1 (0.51) | TP53LMNAHTTCNR1CNR2 | |
| SCHEMBL3658338 | 0.81 | MEN1 (0.46) | TP53LMNAHTTTDP1SLC6A4 | |
| SCHEMBL5188701 | 0.80 | MAPT (0.44) | TP53LMNAHTTCNR1CNR2 | |
| SCHEMBL3630701 | 0.77 | FLT1 (0.35) | TP53LMNAHTTCNR1TDP1 | |
| SCHEMBL11196511 | 0.76 | TP53 (0.44) | TP53LMNAHTTCNR1CNR2 | |
| SCHEMBL9592949 | 0.75 | TP53 (0.52) | TP53LMNAHTTCNR1CNR2 | |
| SCHEMBL11194227 | 0.75 | LMNA (0.43) | TP53LMNAHTTCNR1CNR2 | |
| SCHEMBL3540663 | 0.74 | IDO1 (0.41) | LMNAIDO1TDO2SMN1; SMN2 | |
| SCHEMBL3652018 | 0.73 | CYP19A1 (0.46) | LMNASLC6A2SLC6A4SLC6A3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492784-A2 | SUBSTITUTED 2,3-DIPHENYL PYRIDINES | Merck & Co., Inc. (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082191-A2 | SUBSTITUTED 2,3-DIPHENYL PYRIDINES | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |