Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ANO1 | Q5XXA6 | 15/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627301 | 0.93 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL3629368 | 0.89 | RAB9A (0.64) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL15233172 | 0.89 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL13819650 | 0.89 | ALDH1A1 (0.66) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL13926178 | 0.87 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL28599810 | 0.87 | GRIN2C (0.65) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL12314203 | 0.86 | ALDH1A1 (0.84) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL12314201 | 0.86 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL13819703 | 0.86 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 | |
| SCHEMBL13926784 | 0.85 | ANO1 (0.58) | ALDH1A1HPGDKDM4ECYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263641-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2012-09-11 | — | — | US | claimed |
| EP-2200607-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-05-28 | — | — | US | claimed |
| WO-2009035818-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| US-8524765-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120289587-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8263641-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| EP-2200607-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| WO-2009035818-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289587-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ALDH1A1 4409/4885HPGD 1883/4885KDM4E 4057/4885 |
| US-20090137659-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ALDH1A1 4409/4885HPGD 1883/4885KDM4E 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.