Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298788 | 0.83 | CRBN (0.51) | MAPTCRBNDDB1GAAALDH1A1 | |
| SCHEMBL3571247 | 0.83 | CYP19A1 (0.51) | CRBNDDB1GAAALDH1A1CYP3A4 | |
| SCHEMBL6297778 | 0.79 | GAA (0.51) | CRBNDDB1GAAIDO1RAB9A | |
| SCHEMBL20879956 | 0.79 | CRBN (0.45) | CRBNDDB1POLBMEN1KMT2A | |
| SCHEMBL22623890 | 0.77 | GAA (0.44) | MAPTCRBNDDB1GAAALDH1A1 | |
| SCHEMBL22623851 | 0.77 | GAA (0.44) | MAPTCRBNDDB1GAAALDH1A1 | |
| SCHEMBL22623670 | 0.76 | CRBN (0.41) | MAPTCRBNDDB1GAAALDH1A1 | |
| SCHEMBL22623651 | 0.76 | CRBN (0.41) | MAPTCRBNDDB1GAAALDH1A1 | |
| SCHEMBL22623746 | 0.73 | CRBN (0.45) | MAPTCRBNDDB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22623660 | 0.72 | MAPT (0.45) | MAPTCRBNDDB1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110753703-B | Novel CD73 antibodies, their preparation and use | 德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司） | 2024-04-09 | — | — | CN | disclosed |
| CN-117440798-A | Polymer vesicles comprising soluble encapsulated polynucleotides and ionizable lipids, methods of making and uses thereof | ACM 生物实验室私人有限公司 | 2024-01-23 | — | — | CN | disclosed |
| US-7674886-B2 | Bridged aromatic substituted amine ligands with donor atoms | PONIARD PHARMACEUTICALS, INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-20080227961-A1 | BRIDGED AROMATIC SUBSTITUTED AMINE LIGANDS WITH DONOR ATOMS | PONIARD PHARMACEUTICALS, INC.. | 2008-09-18 | — | — | US | disclosed |
| US-7268220-B2 | Bridged aromatic substituted amine ligands with donor atoms | PONIARD PHARMACEUTICALS, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1813607-A2 | Tetraaza- or N2S2- complexants, and their use in radiodiagnostics or radiotherapy | Poniard Pharmaceuticals, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-0971748-B1 | TETRAAZA- OR N2S2- COMPLEXANTS, AND THEIR USE IN RADIODIAGNOSTICS OR RADIOTHERAPY | PONIARD PHARMACEUTICALS INC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-20050276754-A1 | Bridged aromatic substituted amine ligands with donor atoms | NEORX CORPORATION | 2005-12-15 | — | — | US | disclosed |
| US-6936700-B2 | Bridged aromatic substituted amine ligands with donor atoms | NEORX CORPORATION (US) | 2005-08-30 | — | — | US | disclosed |
| US-20030158393-A1 | Bridged aromatic substituted amine ligands with donor atoms | NEORX CORPORATION (US) | 2003-08-21 | — | — | US | disclosed |
| US-6177551-B1 | SUBSTITUTED METAL CHELATING COMPOUNDS IN WHICH AT LEAST TWO OF THE CHELATING ATOMS ARE NITROGEN WHICH ARE DIRECTLY ATTACHED TO AROMATIC RINGS AND ONE OR MORE OF THOSE NITROGEN ATOMS HAS ATTACHED THERETO A SUBSTITUENT OTHER THAN HYDROGEN | NEORX CORPORATION | 2001-01-23 | — | — | US | disclosed |
| EP-0759913-B1 | AROMATIC AMINE SUBSTITUTED BRIDGED NITROGEN AND SULFUR DONOR ATOM LIGANDS FOR IMAGING | NEORX CORP (US) | 2000-03-01 | — | — | EP | disclosed |
| US-6024937-A | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging | NEORX CORPORATION (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0971748-A2 | TETRAAZA- OR N2S2- COMPLEXANTS, AND THEIR USE IN RADIODIAGNOSTICS OR RADIOTHERAPY | NEORX CORPORATION (US) | 2000-01-19 | — | — | EP | disclosed |
| US-6005083-A | SUBSTITUTED METAL CHELATING COMPOUNDS FOR IMAGING AND THERAPY | NEORX CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |
| WO-1998043678-A2 | TETRAAZA- OR N2S2- COMPLEXANTS, AND THEIR USE IN RADIODIAGNOSTICS OR RADIOTHERAPY | NEORX CORPORATION (US) | 1998-10-08 | — | — | WO | disclosed |
| EP-0759913-A1 | AROMATIC AMINE SUBSTITUTED BRIDGED NITROGEN AND SULFUR DONOR ATOM LIGANDS FOR IMAGING | NEORX CORPORATION (US) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995032192-A1 | AROMATIC AMINE SUBSTITUTED BRIDGED NITROGEN AND SULFUR DONOR ATOM LIGANDS FOR IMAGING | NEORX CORPORATION (US) | 1995-11-30 | — | — | WO | disclosed |
| US-4495365-A | N-Acylsulfonamide herbicidal antidotes | STAUFFER CHEMICAL CO. (US) | 1985-01-22 | — | — | US | disclosed |
| US-4347380-A | N-Acylsulfonamide herbicidal antidotes | STAUFFER CHEMICAL COMPANY (US) | 1982-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050276754-A1 | Bridged aromatic substituted amine ligands with donor atoms | AOC1, DDC, SLC30A5 | MAPT 1594/4885CRBN 2659/4885DDB1 627/4885 |
| US-20080227961-A1 | BRIDGED AROMATIC SUBSTITUTED AMINE LIGANDS WITH DONOR ATOMS | AOC1, DDC, SLC30A5 | MAPT 1594/4885CRBN 2659/4885DDB1 627/4885 |
| US-20030158393-A1 | Bridged aromatic substituted amine ligands with donor atoms | AOC1, DDC, SLC30A5 | MAPT 1594/4885CRBN 2659/4885DDB1 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.