Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632662 | 0.87 | ACE (0.52) | ACEKMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL3624711 | 0.82 | KMT2A (0.38) | ACEALDH1A1TSHRMAPK1KMT2A | |
| SCHEMBL6691029 | 0.79 | TDP1 (0.41) | ACEALDH1A1TSHRMAPK1FKBP1A | |
| SCHEMBL28968201 | 0.74 | HPGD (0.43) | ACEFKBP1ASMN1; SMN2 | |
| SCHEMBL30428928 | 0.73 | HPGD (0.43) | MAPK1FKBP1ASMN1; SMN2 | |
| SCHEMBL9356309 | 0.73 | KMT2A (0.56) | ALDH1A1KMT2A | |
| SCHEMBL9352224 | 0.73 | KMT2A (0.56) | ALDH1A1KMT2A | |
| SCHEMBL4435031 | 0.72 | ACE (0.61) | ACEFKBP1ASMN1; SMN2 | |
| SCHEMBL11197364 | 0.72 | MMP13 (0.53) | ALDH1A1TSHRMAPK1KMT2A | |
| SCHEMBL7270216 | 0.72 | ACE (0.61) | ACEFKBP1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142512-A2 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119825-A2 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |