Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2802000 | 0.90 | TEAD1 (0.53) | TEAD1BCHEACHEBACE1PHGDH | |
| SCHEMBL2802651 | 0.89 | TEAD1 (0.53) | TEAD1BCHEACHEBACE1PHGDH | |
| SCHEMBL2804476 | 0.89 | TEAD1 (0.56) | TEAD1BCHEACHEBACE1PHGDH | |
| SCHEMBL2802531 | 0.87 | TEAD1 (0.54) | TEAD1BCHEACHEBACE1PHGDH | |
| SCHEMBL3629314 | 0.84 | TEAD1 (0.58) | TEAD1BCHEACHEBACE1PHGDH | |
| SCHEMBL13439595 | 0.78 | ACHE (0.46) | TEAD1BCHEACHEBACE1DRD4 | |
| SCHEMBL2806279 | 0.78 | BCHE (0.52) | TEAD1BCHEACHEBACE1EPHX2 | |
| SCHEMBL4569598 | 0.78 | TEAD1 (0.53) | TEAD1BCHEACHEBACE1PHGDH | |
| SCHEMBL2808223 | 0.77 | BCHE (0.51) | TEAD1BCHEACHEBACE1EPHX2 | |
| SCHEMBL3457225 | 0.77 | TEAD1 (0.61) | TEAD1BCHEACHEBACE1PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155225-A1 | METHODS OF TREATMENT OF SKIN ULCERS | The Trustees of the University of Pennsylvania (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-2152865-A1 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS | THOMAS JEFFERSON UNIVERSITY (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008140449-A1 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS | THOMAS JEFFERSON UNIVERSITY (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008140450-A1 | METHODS OF TREATMENT AND PREVENTION OF METABOLIC BONE DISEASES AND DISORDERS | THOMAS JEFFERSON UNIVERSITY (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141176-A1 | METHODS OF TREATMENT OF SKIN ULCERS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-11-20 | — | — | WO | disclosed |