Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634073 | 0.88 | TACR1 (0.44) | SLC6A2SLC6A4SLC6A3TACR1KDM1A | |
| SCHEMBL3814247 | 0.83 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3HTR2CHTR2B | |
| SCHEMBL3633393 | 0.83 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3TACR1KDM1A | |
| SCHEMBL3633857 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL3633063 | 0.78 | CYP3A4 (0.38) | SLC6A2SLC6A4DCUN1D1HTR6TACR1 | |
| SCHEMBL3972485 | 0.77 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3HTR6KDM1A | |
| SCHEMBL3978579 | 0.77 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KDM1AMAOB | |
| SCHEMBL3972421 | 0.77 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR6KDM1A | |
| SCHEMBL3972380 | 0.77 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HTR6KDM1A | |
| SCHEMBL3973401 | 0.76 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148872-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2010-02-03 | — | — | EP | claimed |
| WO-2008128994-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | WO | claimed |
| EP-2148872-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008128994-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | WO | disclosed |