Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633393 | 0.92 | SLC6A2 (0.43) | TACR1SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL3631945 | 0.88 | SLC6A2 (0.51) | TACR1SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL3633857 | 0.84 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL3823147 | 0.84 | TACR1 (0.44) | TACR1CETPSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3627835 | 0.82 | TACR1 (0.44) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3972380 | 0.79 | SLC6A2 (0.39) | SLC6A4SLC6A2SLC6A3KDM1AMAOB | |
| SCHEMBL3978579 | 0.78 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3KDM1AMAOB | |
| SCHEMBL3973401 | 0.76 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3KDM1AMAOB | |
| SCHEMBL3972485 | 0.76 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL3972502 | 0.75 | SLC6A2 (0.39) | SLC6A4SLC6A2SLC6A3KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148872-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2010-02-03 | — | — | EP | claimed |
| WO-2008128994-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | WO | claimed |