Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 5/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633393 | 0.90 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL3972380 | 0.86 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL3634073 | 0.84 | TACR1 (0.44) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL3821333 | 0.82 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3NOS2 | |
| SCHEMBL3972485 | 0.82 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3JAK2JAK3 | |
| SCHEMBL3631945 | 0.82 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL3978579 | 0.82 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL3973401 | 0.80 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL3972502 | 0.79 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL3973888 | 0.79 | IKBKB (0.40) | SLC6A2SLC6A4SLC6A3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148872-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008128994-A1 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | WO | disclosed |