Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11047492 | 0.84 | TRPA1 (0.52) | TRPA1L3MBTL1TP53TDP1CA1 | |
| SCHEMBL29664035 | 0.83 | TRPA1 (0.46) | TRPA1L3MBTL1TP53TDP1CA1 | |
| SCHEMBL23803135 | 0.83 | TRPA1 (0.46) | TRPA1L3MBTL1TP53TDP1CA1 | |
| SCHEMBL2641943 | 0.83 | TRPA1 (0.50) | TRPA1L3MBTL1TP53TDP1CA1 | |
| SCHEMBL6851691 | 0.83 | TRPA1 (0.50) | TRPA1TP53TDP1CA1CA2 | |
| SCHEMBL9796162 | 0.83 | TRPA1 (0.50) | TRPA1TP53TDP1CA1CA2 | |
| SCHEMBL942110 | 0.83 | TRPA1 (0.50) | TRPA1L3MBTL1TP53TDP1CA1 | |
| Ammonia Solution, Strong SCHEMBL17272173 | 0.81 | TRPA1 (0.48) | TRPA1L3MBTL1TP53TDP1CA1 | |
| Ammonia Solution, Strong SCHEMBL17272172 | 0.81 | TRPA1 (0.48) | TRPA1L3MBTL1TP53TDP1CA1 | |
| SCHEMBL17272460 | 0.81 | TRPA1 (0.48) | TRPA1L3MBTL1TP53TDP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170001958-A1 | INHIBITORS OF MITOCHONDRIAL PYRUVATE DEHYDROGENASE KINASE ISOFORMS 1-4 AND USES THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-01-05 | — | — | US | disclosed |
| EP-2655371-B1 | PYRAZOLOPIPERIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2164491-A1 | PIPERIDINE-4-ACETIC ACID DERIVATIVES AND THEIR USE | Euroscreen S.A. (BE) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009010477-A1 | PIPERIDINE-4-ACETIC ACID DERIVATIVES AND THEIR USE | EUROSCREEN S.A. (BE) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001958-A1 | INHIBITORS OF MITOCHONDRIAL PYRUVATE DEHYDROGENASE KINASE ISOFORMS 1-4 AND USES THEREOF | PDK4, PDK2, PDK3 | TRPA1 4719/4885L3MBTL1 1188/4885TP53 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.