Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632088 | 1.00 | MAPT (0.52) | MAPTKDM4ENPC1POLBHTR3E | |
| SCHEMBL19681391 | 0.81 | MAPT (0.57) | MAPTNPC1POLBHTR3EHTR3B | |
| SCHEMBL17041328 | 0.81 | MAPT (0.57) | MAPTNPC1POLBHTR3EHTR3B | |
| SCHEMBL29520009 | 0.81 | MAPT (0.57) | MAPTNPC1POLBHTR3EHTR3B | |
| SCHEMBL3631753 | 0.78 | L3MBTL1 (0.40) | MAPTARMEN1KMT2AMAPK1 | |
| SCHEMBL3631751 | 0.78 | L3MBTL1 (0.40) | MAPTARMEN1KMT2AMAPK1 | |
| SCHEMBL3629916 | 0.78 | POLB (0.50) | MAPTNPC1POLBLMNAALDH1A1 | |
| SCHEMBL3629919 | 0.78 | POLB (0.50) | MAPTNPC1POLBLMNAALDH1A1 | |
| SCHEMBL943697 | 0.77 | MEN1 (0.47) | MAPTKDM4ENPC1LMNAKCNMA1 | |
| SCHEMBL3629402 | 0.76 | KDM4E (0.37) | MAPTKDM4ENPC1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142522-A1 | 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121558-A1 | 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2008-10-09 | — | — | WO | claimed |