Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629398 | 1.00 | KDM4E (0.37) | KDM4EALDH1A1GAAMAPTGABRA1 | |
| SCHEMBL3629396 | 1.00 | KDM4E (0.37) | KDM4EALDH1A1GAAMAPTGABRA1 | |
| SCHEMBL3632088 | 0.76 | MAPT (0.52) | KDM4EALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL3632085 | 0.76 | MAPT (0.52) | KDM4EALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL3629401 | 0.75 | ALDH1A1 (0.36) | KDM4EALDH1A1GAAMAPTGABRA1 | |
| SCHEMBL8220455 | 0.70 | MAPT (0.50) | KDM4EALDH1A1GAAMAPTGABRA1 | |
| SCHEMBL10041862 | 0.70 | MAPT (0.50) | KDM4EALDH1A1GAAMAPTGABRA1 | |
| SCHEMBL10905376 | 0.67 | KMT2A (0.55) | KDM4EALDH1A1GAAMAPTPOLB | |
| SCHEMBL10905375 | 0.67 | KMT2A (0.55) | KDM4EALDH1A1GAAMAPTPOLB | |
| SCHEMBL12544257 | 0.62 | KDM4E (0.56) | KDM4EMAPTGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142522-A1 | 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121558-A1 | 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2008-10-09 | — | — | WO | claimed |